Dr. Brophy

Dr. Brophy is a Pediatric Nephrologist, and, as such, deals with infants and children that suffer from a variety of renal diseases. Dr. Brophy is a member of a variety of National medical organizations. He has also been active with the National Kidney Foundation (NKF), NKF Camps for kids, Polycystic Kidney Foundation and Cystinosis Foundations. He is also a participant in the Acute Dialysis Quality Initiative (www.ADQI.net) and the Acute Kidney Injury Network. He has been a member, Co-Chair and Chair of the Society for Pediatric research- Pediatric Nephrology section program committee. Training:

• BSc Biochemistry- 1988 University of Regina (Canada)
• BA (Hons) Physiological Psychology -1992 University of Saskatchewan (Canada)
• MD (Distinction)- 1994 University of Saskatchewan (Canada)
• Pediatric Residency- 1994-1998 – University of Manitoba (Canada)
• Chief resident- 1997-1998 -University of Manitoba (Canada)
• Pediatric Nephrology Fellowship (Clinical and Basic Science) 1998-2001 University of Michigan
• Lecturer- 2001-2002 University of Michigan
• Assistant professor Pediatrics and communicable diseases 2001-2007 University of Michigan
• Associate Professor and Division Director Pediatric Nephrology, Dialysis & Transplantation 2007- present University of Iowa
• Interdisciplinary program in informatics 2010- present University of Iowa
• Department of surgery 2011- present University of Iowa
• Co-director- child health core of the Iowa Center for clinical and translational research 2011-present

Clinical Interests:

• Perinatal and Developmental nephrology (consultation)
• Acute Kidney Injury and intensive care nephrology
• Dialysis (Peritoneal, Hemodialysis and continuous therapies)
• Therapeutic Plasma Exchange and Hepatic Replacement therapies
• Polycystic Kidney Disease
• Glomerulonephritis and Lupus
• Atypical Hemolytic Uremic Syndrome, Membranoproliferative Glomerulonephritis
• Chronic Kidney Disease
• Nephrotic Syndrome
• Hypertension
• Transplantation
• Rare renal disease/genetics/prenatal renal disease
• Global health and Health care deliver
• Mobile and electronic Health
• Social Media and healthcare applications

Associations and Education:

• Dr. Brophy was recently elected to the Medical Advisory Board of ESRD 12 for a second  3 year term.
• Dr. Brophy is a member of the sub-board for Pediatric Nephrology- American Board of Pediatrics.
• Dr. Brophy was recently elected to council at the American Society of Pediatric Nephrology for a 4 year term.
• Dr. Brophy has regularly participated as faculty in the PREP courses for general Pediatric Board Training and has been certified in adult education principles.
• Dr. Brophy participates in global outreach and has worked with the Issa Trust Foundation  to help establish Pediatric renal dialysis care in Jamaica

Clinical Research:

• North American Pediatric Renal Transplant Cooperative Study
• Acute Kidney injury and extracorporeal treatment methods
• Prospective Pediatric Continuous renal replacement therapy multicenter trial
• Pediatric AKI network
• SCOPE trial member
• International Peritoneal Dialysis initiative- pediatrics
• International HemoDialysis initiative- pediatrics
• Chronic Kidney Disease in Kids National Trial

Translational/Laboratory Interests: The Brophy laboratory focuses on the molecular genetics and functional mechanisms of normal and abnormal development of the kidneys and genitourinary (GU) tract. Translational focuses include metabolomics of acute and chronic kidney diseases and gene rescue therapy for rare renal diseases. Laboratory interests focus on transcription factors and cellular signaling involved with mesenchymal to epithelial transition and metanephrogenesis, as well as identifying genetic lesions involved with selected renal diseases. Current projects include an NIH funded grant Copy number variants in Vesicoureteral reflux. As a result of recent publications related to our work we have initiated and developed a collaborative genetics network (www.kidneygenes.com) in the areas of bilateral renal agenesis and progressive hydronephrosis which are conditions well known to the Pediatric Nephrology community. Potter’s Syndrome Genetics study (www.kidneygenes.com) Congenital progressive hydronephrosis (www.kidneygenes.com